反应详情

Acylation of (4-fluorophenyl)-(4-methylbenzyl)-amine (Pombrik, S. I. et al., Izv. Akad. Nauk. SSSR Ser. Khim., 10, 1981, 2406-2408) with (Z)-2,2-dimethyl-5-(chlorocarbonylmethylene)-1,3-dioxolan-4-one as described in the preparation of Intermediate 71A gave the title amide as a syrup. 1HNMR 400 MHz (CDCl3) δ (ppm): 1.72 (6H, s, CH3), 2.31 (3H, s, CH3) 4.87 (2H, s, NCH2), 5.63 (1H, s, CH), 6.93-7.11 (8H, m, aromatics). HRMS (MAB N2) calculated for C21H20FNO4 [M−]: 369.137637: found: 369.137900.