Ethyl 3,3-bis(4-fluorophenyl)propanoate → 3,3-bis(4-fluorophenyl)propanoic Acid

HRID 392839Notes

Reaction equation

HRID 392839 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][CH:6]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)C>C1C=CC=CC=1.CCCCCC>[F:13][C:10]1[CH:9]=[CH:8][C:7]([CH:6]([C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)[CH2:5][C:4]([OH:21])=[O:3])=[CH:12][CH:11]=1

Participants

3

Reactant 1

HCID 23522917Ethyl 3,3-bis(4-fluorophenyl)propanoate

Product 1

HCID 102208743,3-bis(4-fluorophenyl)propanoic Acid

Reagents, catalysts & solvents 1

HCID 110624Benzene hexaneSolvent

Procedure

Saponification of Intermediate 80A as described in the preparation of Intermediate 1B gave the title acid as white needles: mp 106-107° C. (benzene-hexane). 1HNMR 400 MHz (CDCl3) δ (ppm): 3.05 (2H, d, J=8.1 Hz, CH2), 4.51 (1H, t, J=8.1 Hz, CH), 7.0 (4H, m, aromatics), 7.18 (4H, m, aromatics). Anal. Calcd for C15H12F2O2: C, 68.69; H, 4.61. Found: C, 68.71; H, 4.63.

Workup

  1. customgave the title acid as white needles

Sources & evidence

ORD record
ord-eee3309d848e43f38ef93a74a292c8a7
Source dataset
uspto-grants-2004_10
Patent number
US06803378B2

Reaction notes

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