HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 392865Generated: October 29, 2026
Diethyl Ether → 4-Benzyloxy-5-ethyl-2-methoxy-phenylboronic acid
https://huagongshe.com/reaction/392865
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triethyl borate | HCID 9009 | — |
| Reactant | 1-(Benzyloxy)-4-bromo-2-ethyl-5-methoxybenzene | HCID 22662106 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-Benzyloxy-5-ethyl-2-methoxy-phenylboronic acid | HCID 22662103 | — |
Reaction Steps
The resulting 5-benzyloxy-2-bromo-4-ethyl-1-methoxybenzene (4) is allowed to react with n-butyl lithium in a polar solvent such as ether, glyme or tetrahydrofuran (THF), preferably THF, at a temperature of about −78° C. Triethyl borate is then added to the reaction mixture, and the reaction mixture is allowed to stir at a temperature of about −78° C. The reaction mixture is then allowed to warm to about room temperature. The reaction yields 4-benzyloxy-5-ethyl-2-methoxy-phenylboronic acid (5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06803470B2 |
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| Source dataset | uspto-grants-2004_10 |
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| ORD ID | ord-86949690d9ae4f2aab98c76300429ec7 |
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| Source note | uspto-grants-2004_10 |
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