反应详情

730 mg (1.66 mmol) of tert-butyl 4-[hydroxy(4-methoxy-3-isopropylphenyl)methyl]-3,5-dimethylphenylcarbamate (Example V) are hydrogenated with 700 mg of Pd/C (10%) and with 1 bar of hydrogen at RT for 4 hours. The mixture is filtered through kieselguhr, the solvent is removed in vacuo, and purification by chromatography results in 578 mg (91%) of tert-butyl 4-(4-methoxy-3-isopropylbenzyl)-3,5-dimethylphenylcarbamate.

1. filtrationThe mixture is filtered through kieselguhr
2. customthe solvent is removed in vacuo, and purification by chromatography
3. customresults in 578 mg (91%) of tert-butyl 4-(4-methoxy-3-isopropylbenzyl)-3,5-dimethylphenylcarbamate