HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 4-(3-Isopropyl-4-methoxybenzyl)-3,5-dimethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | tert-Butyl 4-(4-methoxy-3-isopropylbenzyl)-3,5-dimethylphenylcarbamate | HCID 15552186 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 4-(3-Isopropyl-4-methoxybenzyl)-3,5-dimethylaniline | HCID 11289085 | — |
Reaction Steps
578 mg (1.36 mmol) of tert-butyl 4-(4-methoxy-3-isopropylbenzyl)-3,5-dimethylphenylcarbamate (Example VI) are dissolved in 10 ml of 5% trifluoroacetic acid in dichloromethane at 0° C. and stirred for 4 hours. The mixture is neutralized with sodium bicarbonate solution and dried over sodium sulphate. The product after removal of the solvent is reacted further without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06803480B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-16bcfd61df3c4ade9190dba177f59190 |
| Source note | uspto-grants-2004_10 |