Trifluoroacetic acid → HCID 23523300, compound

Participants

Reaction Steps

(2R,3R,4S,5S)(2-{[9-(4-Azido-3-hydroxy-5-methylcarbamoyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-methyl}-4-chloro-phenoxy)-acetic acid tert-butyl ester (1 g, 1.9 mmol) was added to trifluoroacetic acid (15 mL) and stirred at room temperature for 3 hours. The mixture was concentrated and the residue was reconcentrated from chloroform three times to afford the title compound as a foam. M.S. 518 (M+H)+. 1H NMR (400 MHz, CD3OD) δ 8.5 (m, 2H); 7.38 (bs, 1H); 7.25 (d, 1H, J=8.0 Hz); 6.95 (d, 1H, J=8.0 Hz); 6.0 (d, 1H, J=4.0 Hz); 5.0 (m, 1H); 4.85 (m, 2H); 4.75 (s, 2H); 4.4 (m, 2H); 2.8 (s, 3H).

Provenance & Evidence