Triphenylphosphine → HCID 11961748, compound

Participants

Reaction Steps

Triphenylphosphine (1.64 g, 6.24 mmol) was added to a solution of 2-benzyloxy-5-cyano-benzylazide (1.1 g, 4.16 mmol) in anhydrous THF (10 mL) at 0° C. After 1 hour, ammonium hydroxide (0.5 mL) was added and the mixture was warmed to room temperature and stirred overnight. The mixture was concentrated and the residue purified by flash chromatography (3% methanol/dichloromethane) to afford 677 mg (69%) of the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3) δ 7.6-7.3 (m, 7H); 6.95 (d, 1H, J=9.1 Hz); 5.18 (s, 2H); 3.9 (s, 2H).

Provenance & Evidence