反应详情

LAH (136 mg, 3.58 mmol) was added to a solution of 2-benzyloxy-5-trifluoromethyl-benzylazide (1.1 g, 3.58 mmol) at 0° C. After 1 hour, the reaction was quenched by the sequential addition of water (136 μL), 15% NaOH (136 μL), and water (400 μL), the mixture was diluted with dichloromethane and dried with MgSO4, filtered and concentrated. The residue was purified by flash chromatography (3% methanol/dichloromethane) to afford 825 mg (82%) of the title compound as a colorless oil. MS 282 (M+H)+. 1H NMR (400 MHz, CDCl3) δ 7.6-7.3 (m, 7H); 6.92 (d, 1H, J=9.1 Hz); 5.18 (s, 2H); 3.9 (s, 2H); 2.65 (bs, 2H).

1. customthe reaction was quenched by the sequential addition of water (136 μL), 15% NaOH (136 μL), and water (400 μL)
2. additionthe mixture was diluted with dichloromethane
3. dry with materialdried with MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by flash chromatography (3% methanol/dichloromethane)