HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → HCID 58355784, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | tert-Butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate | HCID 22951485 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58355784 | HCID 58355784 | — |
Reaction Steps
A solution of 3-hydroxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester (200 mg, 1.00 mmol) in THF (4 mL) was slowly treated with phosgene 20% in toluene (0.954 mL). After stirring at rt for 16 h, solvents were removed under reduced pressure and co-evaporate with CH2Cl2. The crude 3-chlorocarbonyloxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524764B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-3ec82e7f4b7340b6b11e56dfb62d773e |
| Source note | uspto-grants-2013_09 |