2-Chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acid → 2-Chloro-4-(1-hydroxy-3-(3-hydroxyphenyl)propyl)benzoic acid

HRID 393039Notes

Reaction equation

HRID 393039 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]([OH:22])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].ClC1C=C(C(=O)CCC2C=CC=C(O)C=2)C=CC=1C(O)=O>>[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]([OH:22])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=2)[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 226613772-Chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acidHCID 235607782-Chloro-4-[1-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid, methyl ester

Product 1

HCID 226612282-Chloro-4-(1-hydroxy-3-(3-hydroxyphenyl)propyl)benzoic acidYield 90%

Procedure

This compound was prepared in 90% yield from 2-chloro-4-[1-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid, methyl ester (Example 19) by the procedure described for 2-chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acid (Example 41). The product was a racemic mixture and was not resolved.

Sources & evidence

ORD record
ord-1a9aa6953a1d427ea3e6c7a55de9d6b7
Source dataset
uspto-grants-2004_10
Patent number
US06803384B2

Reaction notes

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