HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[[2-Chloro-4-(tributylstannyl)benzoyl]oxy]-2,5-pyrrolidinedione → N-[2-chloro-4-(tri-n-butylstannyl)benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[[2-Chloro-4-(tributylstannyl)benzoyl]oxy]-2,5-pyrrolidinedione | HCID 15908684 | — |
| Reactant | 3-(thiophene-2-carbonyl)amino-L-alanine | HCID 68820207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[2-chloro-4-(tri-n-butylstannyl)benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine | HCID 68819630 | — |
Reaction Steps
A mixture of 3-(thiophene-2-carbonyl)amino-L-alanine on Wang resin (2.00 g) and 1-[[2-chloro-4-(tributylstannyl)benzoyl]oxy]-2,5-pyrrolidinedione (Example 374; 2.50 g, 4.6 mmol) in N,N-dimethylformamide was shaken for 72 h. The resin was washed with dichloromethane and methanol to give N-[2-chloro-4-(tri-n-butylstannyl)benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine on Wang resin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06803384B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-853d7be51abb47dbaf62a2f330b643a3 |
| Source note | uspto-grants-2004_10 |