Tert-Butyl nitrite → HCID 178518542, compound

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Reaction Steps

2-Amino-5-[[(3-phenoxyphenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7(4H)-one (0.3 g) (product of Example 5) was added over 90 minutes to a solution of t-butyl nitrite (0.17 mL) in tetrahydrofuran (3 mL) at 65° C. After a further 3.5 hours at 65° C., the solvent was evaporated and the residue chromatographed on silica eluting with methanol/dichloromethane mixtures to give the title compound. Yield 0.071 g.

Provenance & Evidence