Pyridine → HCID 178514143, compound

Participants

Reaction Conditions

Reaction Steps

6-Amino-2-[(phenylmethyl)thio]-4-(1H)-pyrimidinone (10.5 g) (prepared as described in WO 96/35678) and potassium thiocyanate (25 g) in dimethylformamide (200 mL) were heated together at 65° C. Pyridine (6.3 mL) was added and the solution cooled to 5° C. Bromine (2.2 mL) was added slowly and the reaction mixture stirred for 2 hours at 5-10° C. The reaction mixture was poured onto ice and water, stirred for 1 hour and the solid was filtered off. After washing with water and ether a pure sample was obtained after tituration with hot methanol.

Provenance & Evidence