Isoamyl Nitrite → 5-[(2,3-difluorophenyl)methylsulfanyl]-4H-[1,3]thiazolo[4,5-d]pyrimidin-7-one

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Example 3 (1.0 g) in tetrahydrofuran (50 ml) was added isoamyl nitrite (3 ml) and the mixture heated at 70° C. for 2 hours. The mixture was evaporated to dryness and purified (SiO2, ethyl acetate:chloroform 1:9 as eluant) to give the title compound (0.61 g).

Provenance & Evidence