Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → 7-Chloro-N-methyl-5-[(phenylmethyl)thio]-thiazolo[4 5-d]pyrimidin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 5-(Benzylthio)-2-bromo-7-chlorothiazolo[4,5-d]pyrimidine | HCID 22052038 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-Chloro-N-methyl-5-[(phenylmethyl)thio]-thiazolo[4 5-d]pyrimidin-2-amine | HCID 22649116 | — |
반응 단계
A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing methylamine (2.0 molar in THF: 0.81 ml) was stirred for 16 hours. The mixture was evaporated to dryness then purified (SiO2, ethyl acetate:dichloromethane 1:9 as eluant) to give the title compound (295 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06806273B1 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-b015c6be86a4456390b77af240e36bd0 |
| 출처 메모 | uspto-grants-2004_10 |