Formamide → 7-Fluoroquinazolin-4(3H)-one

HRID 393227Notes

Reaction equation

HRID 393227 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].O.[CH:13]([NH2:15])=O>>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:15][CH:13]=[N:1]2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 713FormamideHCID 962WaterHCID 27249674-Fluoroanthranilic acid

Product 1

HCID 1353984967-Fluoroquinazolin-4(3H)-one

Procedure

A solution of 2-amino-4-fluorobenzoic acid (3 g) in formamide (30 ml) was heated to 150° C. for 6 hour. The reaction mixture was poured onto a 1:1 mixture of ice and water (250 ml) and the precipitated solid was collected, washed with water and dried to give 7-fluoro-3,4-dihydroquinazolin-4-one (2.6 g).

Workup

  1. customthe precipitated solid was collected
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-f226e220ee6044118602b0aaa912a70c
Source dataset
uspto-grants-2004_10
Patent number
US06806274B1

Reaction notes

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