(E)-4-morpholino-2-buten-1-ol → 4-Methylthio-7-[(e)-4-morpholinobut-2-en-1-yloxy]quinazoline

Participants

Reaction Steps

Using an analogous procedure to that described in the second last paragraph of Note [12] above, (E)-4-morpholinobut-2-en-1-ol (J. Med. Chem., 1972, 15, 110-112; 1.27 g), was reacted with 7-hydroxy-4-methylthioquinazoline (1.2 g) to give 4-methylthio-7-[(E)-4-morpholinobut-2-en-1-yloxy]quinazolin (1.15 g); NMR Spectrum: (CDCl3) 2.45 (br s, 4H), 2.7 (s, 3H), 3.05 (d, 2H), 3.7 (t, 4H), 4.7 (d, 2H), 5.9 (m, 2H), 7.15-7.25 (m, 2H), 7.95 (d, 1H), 8.9 (d, 1H); Mass Spectrum: M+H+ 332.

Provenance & Evidence