Formic Acid → HCID 136388388, compound

HRID 393245Notes

Reaction equation

HRID 393245 reaction equation
[NH2:1][C:2]1[C:11]([C:12](=[O:14])[NH2:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([OH:15])[CH:3]=1.[CH:16](O)=O>>[OH:15][C:4]1[CH:3]=[C:2]2[C:11]([C:12](=[O:14])[NH:13][CH:16]=[N:1]2)=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 22649192HCID 22649192, compound

Product 1

HCID 136388388HCID 136388388, compound

Procedure

A mixture of methyl 4-amino-5-carbamoyl-2-hydroxybenzoate (5.4 g) and formic acid (50 ml) was heated to reflux for 1 hour. The mixture was evaporated. Toluene (75 ml) was added and the mixture was evaporated. The solid residue was washed with methanol and diethyl ether and dried to give methyl 7-hydroxy-4-oxo-3,4-dihydroquinazolin-6-carboxylate (5.2 g); NMR Spectrum: (DMSOd6) 4.9 (s, 3H), 7.09 (s, 1H), 7.39 (s, 1H), 8.5 (s, 1H).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customThe mixture was evaporated
  4. additionToluene (75 ml) was added
  5. customthe mixture was evaporated
  6. washThe solid residue was washed with methanol and diethyl ether
  7. customdried

Sources & evidence

ORD record
ord-850cabeb028b4b338e7ad34e2df0c418
Source dataset
uspto-grants-2004_10
Patent number
US06806274B1

Reaction notes

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