反应详情

温度

70 °C

In a three necked flask, under argon, a suspension of 2-[4-amino-2-oxo-1-pyrrolidinyl]butanamide 393 (6.99 g, 0.037 mol.), dimethoxytetrahydrofurane (5.53 g, 0.041 mol.), pyridine (50.6 ml) and AcOH (36 ml) is warmed to 70° C. and dissolution occurs. After 2 h at this temperature, the reaction is cooled down to room temperature, concentrated in vacuo and the crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v)) to afford 223 as an oil (2.67 g, 30.1%).

1. dissolutiondissolution
2. temperaturethe reaction is cooled down to room temperature
3. concentrationconcentrated in vacuo
4. customthe crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v))