N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide → N-(2-Chloro-5-methoxy-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide

HRID 393381Notes

Reaction equation

HRID 393381 reaction equation
[CH3:1][N:2](CC1C2C(=CC=CC=2)C=CC=1C)[C:3](=[O:23])[C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[CH:8][C:7]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:6][CH:5]=1.[Cl:36][C:37]1[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][C:38]=1[CH2:39]Br>>[Cl:36][C:37]1[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][C:38]=1[CH2:39][N:2]([CH3:1])[C:3](=[O:23])[C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[CH:8][C:7]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 9847336N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamideHCID 124845332-(Bromomethyl)-1-chloro-4-methoxybenzene

Product 1

HCID 10205188N-(2-Chloro-5-methoxy-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide

Procedure

The parent compound was obtained as a white solid in comparable yields according to the procedures described above for the preparation of N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide (Example 19) using 2-chloro-5-methoxy-benzyl bromide instead of 1-chloromethyl-2-methylnaphthalene in step b).

Workup

  1. customThe parent compound was obtained as a white solid
  2. customin comparable yields

Sources & evidence

ORD record
ord-b6fec161afc4499194cdd5cf434474d2
Source dataset
uspto-grants-2004_10
Patent number
US06806370B2

Reaction notes

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