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HRID393410

反应详情

EQUATION

反应方程式

HRID 393410 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)NC(=O)OC(C)(C)C)cc1
HCID688170

N-Boc-p-toluenesulfonamide

C12H17NO4S

结构：CCOC(=O)/N=N/C(=O)OCC
HCID5462977

(E)-Diethyl azodicarboxylate

C6H10N2O4

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)N(C)C(=O)OC(C)(C)C)cc1
HCID22660067

未命名化合物

收率 85%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The crude fluorous DEAD reagent 22 was then used in Mitsunobu reactions with N-Boc-p-toluenesulfonamide. Once again, the standard mode of addition gave complete conversion with MeOH and the product, N-methyl-N-boc-p-toluenesulfonamide was isolated in 85% yield after FSPE. However, the allyl alcohol gave only trace conversion of the starting material. The organic fraction after FSPE was mostly starting material. These results are summarized in Table 7.

WORKUP

后处理

  1. additionOnce again, the standard mode of addition