HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-nitrobenzoic acid → 4-[[(2-methyl-5-nitrophenyl)carbonyl]amino]-N-[[1-(phenylmethyl)cyclopentyl]carbonyl]-L-phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-nitrobenzoic acid | HCID 519683 | — |
| Reactant | 4-amino-N-[[1-(phenylmethyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester | HCID 53841867 | — |
| Product | 4-[[(2-methyl-5-nitrophenyl)carbonyl]amino]-N-[[1-(phenylmethyl)cyclopentyl]carbonyl]-L-phenylalanine | HCID 10128653 | 69% |
Reaction Steps
4-Amino-N-[[1-(phenylmethyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester (35.3 mg, 0.093 mmol) and 2-methyl-5-nitrobenzoic acid 20 mg, 0.11 mmol) were reacted as described in example 34 to give 4-[[(2-methyl-5-nitrophenyl)carbonyl]amino]-N-[[1-(phenylmethyl)cyclopentyl]carbonyl]-L-phenylalanine (34 mg, 69%), HR—FAB—MS: obs. mass 530.2298. Calcd. mass 530.2291 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06806365B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-364aff54fd774a3594276cef60d0f1e7 |
| Source note | uspto-grants-2004_10 |