2-Methyl-5-nitrobenzoic acid → N-[[1-[(4-methoxyphenyl)methyl]cyclopentyl]carbonyl]-4-[[(2-methyl-5-nitrophenyl)carbonyl]amino]-L-phenylalanine

Participants

Role	Name	HCID	Charge
Reactant	2-Methyl-5-nitrobenzoic acid	HCID 519683	—
Reactant	4-Amino-N-[[1[(4-methoxyphenyl)methyl]cyclopentyl]carbonyl]-L-phenylalanine methyl ester	HCID 54485205	—
Product	N-[[1-[(4-methoxyphenyl)methyl]cyclopentyl]carbonyl]-4-[[(2-methyl-5-nitrophenyl)carbonyl]amino]-L-phenylalanine	HCID 10196565	72.1%

Reaction Steps

4-Amino-N-[[1-[(4-methoxyphenyl)methyl]cyclopentyl]carbonyl]-L-phenylalanine methyl ester (23.4 mg, 0.057 mmol) and 2-methyl-5-nitrobenzoic acid 13 mg, 0.07 mmol) were reacted as described in example 40 to give 23 mg (69%) of N-[[1-[(4-methoxyphenyl)methyl]cyclopentyl]carbonyl]-4-[[(2-methyl-5-nitrophenyl)carbonyl]amino]-L-phenylalanine, HR—FAB—MS: obs. mass 560.2413. Calcd. mass 560.2397 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06806365B2
Source dataset	uspto-grants-2004_10
ORD ID	ord-c958310edd7c43bfa56db4bb5505e5f9
Source note	uspto-grants-2004_10