反应详情

To Intermediate (II) (1.10 g, 2.0 mmol) in methanol (50 mL) was added 20% palladium on charcoal (300 mg). The mixture was hydrogenated at 2 bars for 3 hours. The catalyst was filtered through Celite and the solvent concentrated. The resulting oil was purified by column chromatography with silica gel eluting with methylene chloride/methanol (95:5) to give the title compound (0.50 g, 54%) as oil.

1. filtrationThe catalyst was filtered through Celite
2. concentrationthe solvent concentrated
3. customThe resulting oil was purified by column chromatography with silica gel eluting with methylene chloride/methanol (95:5)