Methyl cyclopentanecarboxylate → Methyl 1-(4-chlorobutyl)cyclopentane-1-carboxylate

HRID 393464Notes

Reaction equation

[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14]Br>>[CH3:1][O:2][C:3]([C:5]1([CH2:14][CH2:13][CH2:12][CH2:11][Cl:10])[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4]

Participants

Reactant 2

HCID 78365Methyl cyclopentanecarboxylate

HCID 813641-Bromo-4-chlorobutane

Product 1

HCID 22633554Methyl 1-(4-chlorobutyl)cyclopentane-1-carboxylateYield 64%

Procedure

1-(4-Chlorobutyl)cyclopentane carboxylic acid methyl ester was prepared from cyclopentane carboxylic acid methyl ester and 4-chloro-1-bromobutane using the procedure described in example 7 to give a 64% yield. HR MS (C11H19ClO2): Obs. mass, 218.1072. Calcd. mass, 218.1074, (M+).

Workup

customto give a 64% yield

Sources & evidence

ORD record: ord-ea1c45633c2540fd96b1d407188f4e61
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06806365B2

Reaction notes

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