HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(2-Morpholinyl)ethyl]cyclopentane carboxylic acid → 4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[[1-[(2-morpholinyl)ethyl]cyclopentyl]carbonyl]-L-phenylalanine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(2-Morpholinyl)ethyl]cyclopentane carboxylic acid | HCID 22660220 | — |
| Reactant | 4-(2,6-Dichlorobenzoylamino)-L-phenylalanine methyl ester | HCID 23383933 | — |
| Product | 4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[[1-[(2-morpholinyl)ethyl]cyclopentyl]carbonyl]-L-phenylalanine methyl ester | HCID 69845380 | 62% |
Reaction Steps
4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[[1-[(2-morpholinyl)ethyl]cyclopentyl]carbonyl]-L-phenylalanine methyl ester was prepared from 4-[[(2,6-Dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester and 1-[(2-morpholinyl)ethyl]cyclopentane carboxylic acid using the general coupling procedure described in example 46 to provide a 62% yield. HRMS (C29H35Cl2N3O5): Obs. mass, 576.2531. Calcd. mass, 576.2582, (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06806365B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-dcdd6eaeeebc4c75b1d55b256149b407 |
| Source note | uspto-grants-2004_10 |