反应详情

A solution of 2-chloro-4-trifluoromethyl-5-pyrimidine carboxylic acid benzyl ester in cyclohexene (3 mL, 30 mmole) and ethanol (9 mL) was treated with 10% palladium on carbon and the resulting mixture was heated to reflux for 1 h. The mixture was cooled to room temperature and filtered through a pad of Celite and concentrated to give a quantitative yield of a gummy, off-white solid. LR ES MS (C6H3F3N2O2): 191 (M−H).

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 1 h
3. filtrationfiltered through a pad of Celite
4. concentrationconcentrated
5. customto give a quantitative yield of a gummy, off-white solid