5-Amino-2-chloro-4-fluorophenol → HCID 22646637, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-chloro-6,7-dimethoxyquinoline (0.2 g, 0.89 mmol) and 4-chloro-2-fluoro-5-hydroxyaniline (173 mg, 1 mmol), (as described in EP 61741 A2), in 2-pentanol (2.5 ml) was heated at 120° C. for 6 hours. The resulting solid was collected by filtration, washed with isopropanol and then ether and dried under vacuum to give 4-(4-chloro-2-fluoro-5-hydroxyanilino)-6,7-dimethoxyquinoline hydrochloride (231 mg, 67%) as a white solid.

Provenance & Evidence