反应详情

Concentrated aqueous ammonia solution (30 ml) was added to a solution of (4-fluoro-2-methyl-5-nitrophenyl) methyl carbonate (6 g, 26 mmol), (prepared as described in EP 0307777 A2), in methanol (150 ml) and the mixture stirred for 1 hour at ambient temperature. Most of the organic solvent was removed by evaporation and the residue was partitioned between water and ethyl acetate. The organic layer was separated, dried (MgSO4) and the volatiles removed by evaporation to give 4-fluoro-2-methyl-5-nitrophenol (4.45 g, 100%).

1. customMost of the organic solvent was removed by evaporation
2. customthe residue was partitioned between water and ethyl acetate
3. customThe organic layer was separated
4. dry with materialdried (MgSO4)
5. customthe volatiles removed by evaporation