HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 39361Generated: October 28, 2026
Water → tert-butyl 2-acetamido-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
https://huagongshe.com/reaction/39361
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | tert-butyl 2-amino-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate | HCID 11357283 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | tert-butyl 2-acetamido-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate | HCID 47146196 | — |
Reaction Steps
As shown in step 10-ii of Scheme 10, to Compound 1033 (10.0 g) in pyridine (80 mL) was added acetyl chloride (4.2 mL). After stirring at 50° C. for 30 min, water (200 mL) was added. The resulting solid was collected by filtration and washed with water (2×) gave tert-butyl 2-acetamido-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (Compound 1034, 10.873 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08524906B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-86a05d7862404684a1143e751007b1c9 |
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| Source note | uspto-grants-2013_09 |
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