4-Chloro-2-fluoroaniline → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)quinoline hydrochloride

Participants

Reaction Conditions

Reaction Steps

A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)quinoline hydrochloride (3 g, 9.8 mmol), (prepared as described for the starting material in Example 5), and 4-chloro-2-fluoroaniline (2.2 ml, 19.6 mmol) in DMF (50 ml) was heated at 150° C. for 30 minutes. After dilution with isopropanol (50 ml), the precipitate was collected by filtration and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)quinoline hydrochloride (2.05 g, 50%).

Provenance & Evidence