5-Amino-4-fluoro-2-methylphenol → HCID 22646552、化合物

関与物質

反応手順

A mixture of 4-chloro-6,7-dimethoxyquinoline hydrochloride (360 mg, 1.4 mmol), (prepared as described for the starting material in Example 2), and 2-fluoro-5-hydroxy-4-methylaniline (212 mg 1.5 mmol), (prepared as described for the starting material in Example 1), in isopropanol (15 ml) was heated at reflux for 3 hours. The mixture was allowed to cool and the solid product was collected by filtration, washed with acetone and dried to give 6,7-dimethoxy-4-(2-fluoro-5-hydroxy-4-methylanilino)quinoline hydrochloride (146 mg, 29%).

情報源と証拠