Methyl 4-[(chlorosulfonyl)methyl]oxane-4-carboxylate → 4-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Methyl 4-[(chlorosulfonyl)methyl]oxane-4-carboxylate	HCID 22228396	—
Reactant	2-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]-3-methylbutyric acid	HCID 22646676	—
Reactant	1-(4-Pyridin-3-yl-phenyl)piperazine	HCID 22646684	—
Product	4-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid methyl ester	HCID 69895116	55%

Reaction Steps

Prepared according to the method for the preparation of 2-[4-(4-bromophenyl)piperazine-1-sulfonylmethyl]-3-methyl-butyric acid tert-buryl ester, from 1-(4-pyridin-3-yl-phenyl)piperazine (0.18 g) and 4-chlorosulfonylmethyl tetrahydropyran-4-carboxylic acid methyl ester (0.23 g), to yield the title compound as a white solid (0.19 g, 55%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06809100B2
Source dataset	uspto-grants-2004_10
ORD ID	ord-51c94156a9594802afc1e3001c1330ab
Source note	uspto-grants-2004_10