Ethylamine → N-ethyl-N,N-bis[2-(tert-butoxycarbonylamino)-3-cyclohexylpropyl]amine

HRID 39370Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:10]O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:19]([NH2:21])[CH3:20]>>[CH2:19]([N:21]([CH2:10][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:10][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH3:20]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 11043405(S)-(-)-2-(tert-Butoxycarbonylamino)-3-cyclohexyl-1-propanol

Product 1

HCID 60204727N-ethyl-N,N-bis[2-(tert-butoxycarbonylamino)-3-cyclohexylpropyl]amine

Procedure

The product from Example 15A and ethylamine were processed as described in Example 7B to provide the title compound.

Sources & evidence

ORD record: ord-906d499d5cc240689b3ae4b3e44044d2
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08524753B2

Reaction notes

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