5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 4-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}tetrahydropyran-4-carboxylic acid

HRID 393705Notes

Reaction equation

HRID 393705 reaction equation
BrC1C=CC([N:8]2[CH2:13][CH2:12][N:11]([S:14]([CH2:17][C:18]3([C:24]([OH:26])=[O:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)(=[O:16])=[O:15])[CH2:10][CH2:9]2)=CC=1.Cl.Cl.[F:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:37]=[N:38][C:39](N3CCNCC3)=[N:40][CH:41]=2)=[CH:32][CH:31]=1.COC(C1(S(Cl)(=O)=O)CCOC(C)C1)=O>>[F:29][C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[N:40][C:39]([N:8]3[CH2:13][CH2:12][N:11]([S:14]([CH2:17][C:18]4([C:24]([OH:26])=[O:25])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)(=[O:15])=[O:16])[CH2:10][CH2:9]3)=[N:38][CH:37]=2)=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 226466794-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acidHCID 865902444-Chlorosulfonyl-methyltetrahydropyran-4-carboxylic acid methyl ester

Product 1

HCID 226467234-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}tetrahydropyran-4-carboxylic acidYield 81%

Procedure

Prepared according to the method for the preparation of 4-[4-(4-bromophenyl) -piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid, from 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride (0.27 g), and 4-chlorosulfonyl -methyltetrahydropyran-4-carboxylic acid methyl ester (0.25 g), to yield the title compound as white solid (0.31 g, 81%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d882af0c80a94046b1d8fcfb888aff72
Source dataset
uspto-grants-2004_10
Patent number
US06809100B2

Reaction notes

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