HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 4-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride | HCID 22646672 | — |
| Reactant | 4-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester | HCID 69895707 | — |
| Product | 4-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine dihydrochloride | HCID 22646693 | 89% |
Reaction Steps
Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(4-fluorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (0.146 g), to provide the title compound as a white solid (0.120 g, 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809100B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-687ab202f11b4e2ba79244c3e163a671 |
| Source note | uspto-grants-2004_10 |