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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 393716Generated: October 25, 2026

4-Fluorophenylboronic acid → 4-[5-(4-Fluorophenyl)pyridin-2-yloxy]piperidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/393716

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactanttert-Butyl 4-((5-bromopyridin-2-yl)oxy)piperidine-1-carboxylateHCID 21914479—
ReactantTert-butyl 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylateHCID 69850026—
Product4-[5-(4-Fluorophenyl)pyridin-2-yloxy]piperidine-1-carboxylic acid tert-butyl esterHCID 6989666834%

Reaction Steps

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromo-pyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester (0.39 g) and 4-fluorophenylboronic acid (0.16 g), to yield the title compound as a white solid (0.13 g, 34%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06809100B2
Source datasetuspto-grants-2004_10
ORD IDord-fffd60e0c2ca47ae8b24c4303f8ad1a2
Source noteuspto-grants-2004_10