HRID393718

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22646730

未命名化合物

结构：CC(C)[C@@H](CS(=O)(=O)Cl)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1

HCID22888284

未命名化合物

结构：CC(C)C(CS(=O)(=O)N1CCN(c2ccc(Br)cc2)CC1)C(=O)OC(C)(C)C

HCID69895250

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@@H](CS(=O)(=O)N1CCC(Oc2ccc(-c3ccc(F)cc3)cn2)CC1)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1

HCID23519752

未命名化合物

收率 75.3%

PROCEDURE

实验过程

Prepared according to the method for the preparation of 2-[4-(4-bromophenyl)-piperazine-1-sulfonylmethyl]-3-methyl-butyric acid tert-butyl ester, from 5-(4-fluorophenyl)-2-(piperidin-4-yloxy)pyridine (0.52 g) and 4-(R)-Benzyl-3-(2-(R)-chlorosulfonylmethyl-3-methylbutyryl)oxazolidin-2-one (0.57 g) to yield the title compound as an off-white solid (0.70 g, 58%).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9c1f27676d1449e88bc6ed71d166cd1e
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809100B2
来源说明: uspto-grants-2004_10

反应 SMILES

C(OC(=O)C(CS(N1CCN(C2C=CC(Br)=CC=2)CC1)(=O)=O)C(C)C)(C)(C)C.[F:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:37]=[CH:38][C:39]([O:42][CH:43]3[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]3)=[N:40][CH:41]=2)=[CH:32][CH:31]=1.[CH2:49]([C@@H:56]1[CH2:60][O:59][C:58](=[O:61])[N:57]1[C:62](=[O:72])[C@H:63]([CH2:67][S:68](Cl)(=[O:70])=[O:69])[CH:64]([CH3:66])[CH3:65])[C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1>>[CH2:49]([C@@H:56]1[CH2:60][O:59][C:58](=[O:61])[N:57]1[C:62](=[O:72])[C@H:63]([CH2:67][S:68]([N:46]1[CH2:47][CH2:48][CH:43]([O:42][C:39]2[CH:38]=[CH:37][C:36]([C:33]3[CH:32]=[CH:31][C:30]([F:29])=[CH:35][CH:34]=3)=[CH:41][N:40]=2)[CH2:44][CH2:45]1)(=[O:70])=[O:69])[CH:64]([CH3:66])[CH3:65])[C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1