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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 393720Generated: October 25, 2026

3-(1,3,2-Dioxaborinan-2-yl)pyridine → 4-(5-Pyridin-3-ylpyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/393720

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(1,3,2-Dioxaborinan-2-yl)pyridineHCID 4198005—
Reactanttert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylateHCID 21914476—
ReactantTert-butyl 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylateHCID 69850026—
Product4-(5-Pyridin-3-ylpyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl esterHCID 6989498799%

Reaction Steps

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.403 g) and pyridine-3-boronic acid 1,3-propanediol cyclic ester (0.211 g), to yield the title compound as an orange solid (0.399 g, 99%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06809100B2
Source datasetuspto-grants-2004_10
ORD IDord-ba4d2f23235b412f94001f315bb331a1
Source noteuspto-grants-2004_10