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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 393721Generated: October 25, 2026

5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 2-Piperazin-1-yl-5-pyridin-3-ylpyrimidine, trihydrochloride

https://huagongshe.com/reaction/393721

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 22646672—
Reactant4-(5-Pyridin-3-ylpyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl esterHCID 69894987—
Product2-Piperazin-1-yl-5-pyridin-3-ylpyrimidine, trihydrochlorideHCID 13172458196%

Reaction Steps

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-(5-pyridin-3-ylpyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (0.399 g), to furnish the title compound as an off-white solid (0.393 g, 96%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06809100B2
Source datasetuspto-grants-2004_10
ORD IDord-cfec2471a72747a9a519aaaab2623109
Source noteuspto-grants-2004_10