huagongshe.com
HRID393724

反应详情

EQUATION

反应方程式

HRID 393724 的结构方程式

REACTANTS

反应物

3
结构：N#Cc1ccc(B(O)O)cc1
HCID2734326

4-Cyanophenylboronic acid

C7H6BNO2

结构：CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cn2)CC1
HCID21914476

tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

C13H19BrN4O2

结构：CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
HCID69850026

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(C#N)cc3)cn2)CC1
HCID69894083

未命名化合物

收率 68%

PROCEDURE

实验过程

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (1.00 g) and 4-cyanobenzeneboronic acid (0.47 g), to yield the title compound as a white solid (0.72 g, 68%).

WORKUP

后处理

  1. customPrepared