HRID393782

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCC[C@@H]2CNC[C@@H]21

HCID1519436

未命名化合物

HCID2734414

5-Bromo-2-chloropyridine

C5H3BrClN

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC[C@@H]2CN(c3ccc(Cl)nc3)C[C@@H]21

HCID86584375

未命名化合物

收率 49%

PROCEDURE

实验过程

tert-Butyl cis-octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate (374 mg, 1.65 mmol), prepared as described in (EP0603887 A2) and 5-bromo-2-chloropyridine (314 mg, 1.65 mmol), prepared as described in (Tetrahedron Lett. (1998), 39, 2059-2062) were processed as described in Example 1E to provide the title compound (273 mg, 49% yield). MS (DCI/NH3) m/z 338/340 (M+H)+.

WORKUP

后处理

customprepared