Acetic Acid → HCID 11855511, Verbindung

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Acetic Acid	HCID 176	—
Edukt	Benzaldehyde	HCID 240	—
Edukt	Sodium triacetoxyborohydride	HCID 5049666	—
Edukt	N-[(2R)-2-(thiazol-5-ylmethoxycarbonylamino)-3-phenylpropyl]-N-[(2S)-2-(thiazol-5-ylmethoxycarbonylamino)-3-phenylpropyl]amine	HCID 60204702	—
Produkt	HCID 11855511	HCID 11855511	39,3%

Reaktionsschritte

The product from Example 26D (87.5 mg, 0.155 mmol), benzaldehyde (19 μl, 0.186 mmol), acetic acid (11 μl, 0.181 mmol), and sodium triacetoxyborohydride (53 mg, 0.248 mmol) were processed as described in Example 27 to provide the title compound (40 mg, 39%). 1H NMR (CDCl3) δ 8.72 (s, 2H), 7.80 (s, 2H), 7.32-6.95 (m, 15H), 5.21 (s, 4H), 4.65 (br s, 2H), 3.93 (br s, 2H), 3.56 (s, 2H), 2.78 (dd, 2H), 2.66 (br s, 2H), 2.45 (d, 4H); MS (ESI+) m/z 656 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08524753B2
Quelldatensatz	uspto-grants-2013_09
ORD ID	ord-8af958c0a97a46b690e1639292eb40f6
Quellennotiz	uspto-grants-2013_09