Fumaric Acid → HCID 86584387, compound

HRID 393823Notes

Reaction equation

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([N:8]2[C@H:15]3[C@H:10]([CH2:11][CH2:12][NH:13][CH2:14]3)[CH2:9]2)=[CH:4][C:3]=1[CH3:16].[C:17]([OH:24])(=[O:23])/[CH:18]=[CH:19]/[C:20]([OH:22])=[O:21]>>[C:17]([OH:24])(=[O:23])/[CH:18]=[CH:19]/[C:20]([OH:22])=[O:21].[Cl:1][C:2]1[N:7]=[CH:6][C:5]([N:8]2[C@H:15]3[C@H:10]([CH2:11][CH2:12][NH:13][CH2:14]3)[CH2:9]2)=[CH:4][C:3]=1[CH3:16]

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 9834620HCID 9834620, compound

Product 1

HCID 86584387HCID 86584387, compoundYield 70%

Procedure

The product of Example 89B (0.850 g, 0.359 mmol) and fumaric acid (42 mg, 0.359 mmol) were processed according to the procedure described in Example 66D to provide the title compound (97 mg, 0.250 mmol, 70% yield). 1H NMR (CH3OH-d4, 300 MHz) δ2.05 (m, 1H), 2.30 (m, 1H), 2.32 (s, 3H), 2.85 (m, 1H), 3.15 (ddd, J=12.5, 8.1, 4.4 Hz, 1H), 3.31 (m, 1H), 3.57 (ddd, J=12.5, 8.5, 4.1 Hz, 1H), 3.64 (dd, J=14.6, 2.0 Hz, 1H), 3.77 (dd, J=7.1, 2.3 Hz, 1H), 3.83 (t, J=7.4 Hz, 1H), 4.34 (dt, J=7.8, 2.3 Hz, 1H), 6.69 (s, 2H), 7.04 (d, J=2.8 Hz, 1H), 7.57 (d, J=2.8 Hz, 1H); MS (DCI/NH3) m/z 238 (M+H-C4H4O4)+; Anal. calculated for C12H16ClN3.1.3C4H4O4: C, 53.16; H, 5.50; N, 10.81; Found: C, 52.91; H, 5.62; N, 10.86.

Sources & evidence

ORD record: ord-96945db756fa40d0ba1e69dc9bf1b534
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809105B2

Reaction notes

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