Trifluoroacetic acid → HCID 91407828, compound

Participants

Reaction Steps

Example 36 was synthesized in accordance with the methods of Example 33, except that 4-(3-cyclohexyl-3-hydroxy-1-propynyl)-benzoic acid, 2-(phenylsulfonyl)hydrazide (Example 35) was used instead of 4phenacetylenyl-benzoic acid, 2-(phenylsulfonyl)hydrazide. MS: 403 (M+1 for C21H26N2O4S1); mp 158-159° C.; TLC (SiO2) Rf=0.3 (50% EtOAc/hexanes); HPLC (C18 column, 7:3 CH3CN/H2O+0.1%TFA) 95%, RT=5.0 min. 1H NMR (DMSO-d6) δ 1.10-1.65 (m, 12H), 2.46-2.61 (m, 2H), 4.00 (s, 1H), 7.20 (d, 2 H, J=8.1 Hz), 7.46-7.57 (m, 5H), 7.78 (d, 2H, J=7.3 Hz), 9.93 (s, 1H, 10.56 (s, 1H).

Provenance & Evidence