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3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide → 5-{[4-(4-Aminophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide | HCID 21918554 | — |
| 反応物 | HCID 21918696 | HCID 21918696 | — |
| 生成物 | 5-{[4-(4-Aminophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol | HCID 21918631 | 61% |
反応手順
The experimental protocol used is the same as that described for intermediate 2.2, with 5-{[4-(4-nitrophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide. A beige powder is obtained with a yield of 61%. This is used directly in the following stage without additional purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809088B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-caf7523784c8430783e440b062e4c6e6 |
| 出典メモ | uspto-grants-2004_10 |