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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 393864Generated: October 29, 2026

4-Morpholinecarbonyl chloride → HCID 131723646, compound

https://huagongshe.com/reaction/393864

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Morpholinecarbonyl chlorideHCID 84810—
ReactantHCID 22858196HCID 22858196—
SolventPyridineHCID 1049—
ProductHCID 131723646HCID 131723646—

Reaction Steps

Morpholino-Ser(OBn) was prepared from N-Fmoc-Ser(OBn). Esterification of N-Fmoc-Ser(OBn) with isobutylene in the presence of a catalytic amount of H2SO4 afforded N-Fmoc-Ser(OBn)-OtBu. The Fmoc group was removed with piperidine in CH2Cl2 to produce Ser(OBn)-OtBu. Reaction of Ser(OBn)-OtBu with 4-morpholinecarbonyl chloride in pyridine yielded morpholino-Ser(OBn)-OtBu. Morpholino-Ser(OBn)-OtBu was hydrolyzed with TFA in CH2Cl2 to yield morpholine-Ser(OBn).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06809176B2
Source datasetuspto-grants-2004_10
ORD IDord-ed72e8413e974951998324314bcf4eb4
Source noteuspto-grants-2004_10