反应详情

A 50-mL single neck round bottom flask was charged with 4-cyanophenyl 4-methylbenzoate (2.65 g, 11.2 mmol), 4,4-dimethyl-1,3-cyclohexanedione (2.10 g, 15 mmol) and acetonitrile (15 mL). Then triethylamine (2.5 g, 25 mmol) and acetone cyanohydrin (0.14 mL, 1.5 mmol) were added and the mixture was refluxed for 6 hours. Volatiles were stripped from the reaction mixture and the residue was partitioned between diethyl ether (100 mL) and water (50 mL). The organic layer was extracted with saturated aqueous sodium bicarbonate (30 mL), then water (10 mL), then brine (10 mL). All aqueous layers were combined and 1N hydrochloric acid was added to pH 1. The resulting oil was extracted into dichloromethane (30 mL, 2×15 mL). The dichloromethane layers were combined, dried over magnesium sulfate, filtered and stripped to a brown oil (3.57 g). The crude product was chromatographed on silica gel (200 g), eluting with hexanes-ethyl acetate (4:1). Fractions containing pure product were concentrated to a yellow oil (2.08 g), which was crystallized from hexanes to afford the title compound as off-white crystals, 1.35 g (46.8%), m.p. 78-79° C. 1H NMR (DMSO-d6): δ 1.08 (s, 6), 1.84 (m, 2), 2.36 (s, 3), 2.61 (m, 2), 7.26 (d, 2), 7.60 (d, 2).

1. temperaturethe mixture was refluxed for 6 hours
2. customthe residue was partitioned between diethyl ether (100 mL) and water (50 mL)
3. extractionThe organic layer was extracted with saturated aqueous sodium bicarbonate (30 mL)
4. addition1N hydrochloric acid was added to pH 1
5. extractionThe resulting oil was extracted into dichloromethane (30 mL, 2×15 mL)
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. customThe crude product was chromatographed on silica gel (200 g)
9. washeluting with hexanes-ethyl acetate (4:1)
10. additionFractions containing pure product
11. concentrationwere concentrated to a yellow oil (2.08 g), which
12. customwas crystallized from hexanes