Carbon Dioxide → HCID 178516425, compound

HRID 393949Notes

Reaction equation

HRID 393949 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1C(O)=O.C(=O)=O>>[F:15][C:12]([F:13])([F:14])[C:8]1[CH:7]=[C:6]2[C:11]([C:2]([OH:1])=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 280Carbon DioxideHCID 178524718HCID 178524718, compound

Product 1

HCID 178516425HCID 178516425, compoundYield 98.6%

Procedure

A round bottom flask was charged with 4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylic acid (34.1 g, 0.132 mol) and then heated in a Wood's metal bath for 5 minutes during which time carbon dioxide evolution was observed and the material changed from a solid to a liquid. After 5 minutes no further gas evolution was noted so the flask was removed from the bath and allowed to cool to ambient temperature. The resulting solid was isolated by filtration to provide 27.75 g of 7-(trifluoromethyl)-4-quinolinol.

Workup

  1. customwas removed from the bath
  2. customThe resulting solid was isolated by filtration

Sources & evidence

ORD record
ord-c108c972f2ce45c2bab7255dc5582bc9
Source dataset
uspto-grants-2004_10
Patent number
US06809203B2

Reaction notes

Loading…