Benzhydrylpiperazine → HCID 131724627, compound

Participants

Reaction Steps

N-(3,4-Dimethoxybenzenesulfonyl)-[(2S,4S)-4-phenoxy-2-pyrrolidinecarboxylic acid] (10) (0.64 g; 1.57 mmol) is dissolved in methylene chloride (15 mL) at ambient temperature. 1-(Diphenylmethyl)piperazine (0.48 g; 1.89 mmol), N,N-diisopropylethylamine (0.45 g; 3.46 mmol) and PyBOP (0.98 g; 1.89 mmol) are added sequentially. The reaction is stirred for 16 hours at room temperature, then concentrated under reduced pressure. The residue is purified via silica gel chromatography (40%→50% ethyl acetate in hexanes) affording the desired product as a solid foam. CIMS: MH+ 642

Provenance & Evidence